… the role of altered DNA methylation in cancer. Global hypomethylation in some models promotes
and in other models protects cancer … The complexity of DNA methylation makes hard to …

… between DNMT inhibitors and chemotherapeutic drugs make combining epigenetic therapy
and … Moreover, DNMT inhibitors can reverse epidermal growth factor (EGF) receptor (EGFR) …

… (DNMTs) to specific genomic loci to promote DNA methylation [19,20,21]. On the … DNA
methylation and histone modification machinery critical for maintaining the cellular epigenetic …

… undergoing clinical stage investigations in different cancer … of the epigenetic therapy
through the implementation of emerging … DNA methylation is an epigenetic process that can be …

… with crucial roles in epigenetic regulation. They have been considered as promising
therapeutic targets for the epigenetic treatment of cancer. Therefore, DNMT inhibitors (DNMTis) …

… of DNA methylation by DNMTs and specifically introduces this process in the context of tumor
… Similarly, Vendetti et al. proposed epigenetic treatments that target DNMTs and HDACs in …

… Epigenetic modifications, including DNA methylation and demethylation and histone …
Hence, epigenetic therapy has emerged as a rapidly advancing field of cancer research. A …

… regulation [Table 2], and trials on epigenetic therapies (using DNA methyltransferase [DNMT…
epigenetic therapy with DNA methyltransferase inhibitors and histone deacetylase inhibitors …

… to extend our understanding of DNA methylation and its implication in several diseases. The
… field for DNMT inhibition. However, efficient and potent targeting of DNA methylation in cells …

… for anticancer therapies, enabling the resetting of cancer epigenome. Based … epigenetic
drugs can be classified into DNA methylation inhibitor (DNMTi) and histone deacetylase inhibitor …